The primary outcome was all-cause mortality within 28 days after randomization; further analyses were specified at 6 months. Secondary outcomes were the time until discharge from the hospital and, among patients not receiving invasive mechanical ventilation at the time of randomization, subsequent receipt of invasive mechanical ventilation (including extracorporeal membrane oxygenation) or death. Other prespecified clinical outcomes included cause-specific mortality, receipt of renal hemodialysis or hemofiltration, major cardiac arrhythmia (recorded in a subgroup), and receipt and duration of ventilation.
Protocol detail
Mortality Outcomes in COVID-19
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Other organizations : University Hospitals Birmingham NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, National Institute for Health Research, University of Oxford
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Variable analysis
independent variables
- Not explicitly mentioned
- All-cause mortality within 28 days after randomization
- Time until discharge from the hospital
- Subsequent receipt of invasive mechanical ventilation (including extracorporeal membrane oxygenation) or death (among patients not receiving invasive mechanical ventilation at the time of randomization)
- Cause-specific mortality
- Receipt of renal hemodialysis or hemofiltration
- Major cardiac arrhythmia (recorded in a subgroup)
- Receipt and duration of ventilation
- Not explicitly mentioned
- No positive or negative controls specified
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