In a 100 mL round bottom flask, 1 equiv of phthalic anhydride and 1 equiv of amine were placed provided with a reflux condenser (Scheme 1). Forty milliliters of glacial acetic acid was added as a solvent. The mixture of reaction was refluxed with stirring for 1 h at(room temp) so that imide was synthesized. Glacial acetic acid was eliminated by extracting the mixture of reaction with water, ethyl acetate, and chloroform. The crude product was purified using column chromatography giving a yield of 94–96%.
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Karim N., Khan I., Khan I., Halim S.A., Khalid A., Abdalla A.N., Rehman N.U., Khan A, & Al-Harrasi A. (2023). Antiamnesic Effects of Novel Phthalimide Derivatives in Scopolamine-Induced Memory Impairment in Mice: A Useful Therapy for Alzheimer’s Disease. ACS Omega, 8(8), 8052-8065.
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