2D-SWE was performed using the Aixplorer ultrasound system (Supersonic Imagine, France). Liver stiffness was measured in kilopascals (kPa) and expressed in a 0-4 scoring system, corresponding to the manufacturer-recommended histologic METAVIR scale related to the stage of liver fibrosis, with appropriate ranges separately proposed for HBV, HCV infections and non-alcoholic steatohepatitis (NASH). It is worth noting that the proposed cut-offs have been changing as the results of larger studies providing new data became available. Currently (since 2015), manufacturer-recommended cut-offs for HCV infection and NASH indicate F0-1 for < 7.1 kPa, F2 for 7.1-9.2 kPa, F3 for 9.2-13.5 kPa, and F4 for liver stiffness of > 13.5 kPa. In HBV infection the proposed cut-offs are: < 7.1 kPa for F0-1, 7.1-8.1 kPa for F2, 8.1-11.5 kPa for F3 and > 11.5 kPa for F4 [9 (link)].
Protocol detail
Liver Fibrosis Staging by 2D-SWE
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Corresponding Organization : Medical University of Białystok
Other organizations : University Clinical Hospital In Bialystok
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Variable analysis
independent variables
- Liver stiffness measured in kilopascals (kPa)
- Liver fibrosis stage classification (F0-1, F2, F3, F4)
- Ultrasound system (Aixplorer ultrasound system by Supersonic Imagine, France)
- Liver fibrosis staging methodology (manufacturer-recommended histologic METAVIR scale)
- Liver fibrosis stage cut-off values for HBV, HCV, and NASH
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