We confirm that the work has been reported in line with the Strengthening The Reporting Of Cohort Studies in Surgery (STROCSS) criteria13 (link).
Retrospective Cohort Study of ILD Diagnosis
We confirm that the work has been reported in line with the Strengthening The Reporting Of Cohort Studies in Surgery (STROCSS) criteria13 (link).
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Corresponding Organization :
Other organizations : University of Aleppo
Variable analysis
- Flexible bronchoscopy (Olympus BF type PE2) under local anesthesia using xylocaine (4% spray – 2% instillation through the working channel)
- Transbronchial lung biopsy (TBLB) using disposable biopsy forceps (Olympus, model no. FB-231D, working length: 1150 mm, minimum channel size: 2.0 mm)
- Results of biopsies studied in the Histopathology Department of Aleppo University Hospital
- Patients were referred or hospitalized to the respiratory department at Aleppo University Hospital, Syria
- Patients were above 18 years old
- Diagnosis of diffuse parenchymal lung disease was made based on HRCT and clinical findings, excluding other respiratory diseases such as tuberculosis and COVID-19
- Patients had no contraindications to conduct bronchoscopy or TBLB, such as hypoxia, cardiac arrhythmias, or hemorrhage abnormalities
- Patients had CT pathognomonic patterns that followed the diagnosis criteria of ILD
- Patients had typical manifestations and clinical history of connective tissue disease-associated ILDs, such as rheumatoid arthritis, systemic sclerosis, or systemic lupus erythematosus
- Patients were diagnosed with occupational lung disease based on clinical, radiological, and laboratory examinations
- Patients diagnosed with COVID-19 or tuberculosis were confirmed using nasal smear PCR or sputum gene Xpert MTP/RIF, respectively
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