Genetic Ancestry Assessment in HIS Veterans

HIS Veterans are more genetically admixed than EUR Veterans (18 (link)); thus, we evaluated GRS performance in a subset of HIS Veterans with less than 50% EUR global genetic ancestry (GGA) as determined via the ADMIXTURE software program (20 (link)). We compared these subset results to the full MVP HIS POAG case-control dataset.

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Waksmunski A.R., Kinzy T.G., Cruz L.A., Nealon C.L., Halladay C.W., Anthony S.A., Greenberg P.B., Sullivan J.M., Wu W.C., Iyengar S.K., Crawford D.C., Peachey N.S, & Bailey J.N. (2023). Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 28, 413-424.

Publication 2023

Genetic Poag Veterans

Corresponding Organization :

Other organizations : Cornell University, Case Western Reserve University, VA Northeast Ohio Healthcare System, Providence VA Medical Center, Brown University, Providence College, VA Western New York Healthcare System, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland Eye Clinic

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Variable analysis

independent variables

Subset of HIS Veterans with less than 50% EUR global genetic ancestry (GGA) as determined via the ADMIXTURE software program

dependent variables

GRS performance

control variables

Full MVP HIS POAG case-control dataset

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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