Salmonella Typhi and Salmonella Paratyphi are statutorily notifiable in England: local health protection teams are routinely requested to complete enhanced surveillance questionnaires of all notified cases for local management and national reporting. Surveillance system includes individuals who present to primary care/hospital and have a sample taken (blood or stool) which results in a positive Salmonella Typhi/Paratyphi culture. Responses to the Enhanced Surveillance of Enteric Fever Questionnaire (Supplementary Questionnaire) were extracted from data held in the enhanced typhoid and paratyphoid surveillance database for all cases in England for 2015–2019 and were merged to achieve an adequate sample size. The questionnaire is a self-administered online survey. Once a case completes it, the questionnaire is automatically sent to the local Health Protection Team and the UKHSA Travel Health and International Health Regulations Team. The gap between a positive Salmonella Typhi/Paratyphi culture and form administration is 24 h. The study dataset covers fields such as ethnicity, travel history, symptoms, antibiotic administration or vaccination history, absence from school and work as well as history of hospital admission. Responders who did not provide a valid UK postcode in the questionnaire were excluded from the analyses as IMD and relevant population denominators could not have been estimated. Duplicate cases were excluded. Chronic cases were also excluded as date of onset of the infection could not be estimated. Cases who had data missing from sex, ethnicity, symptom severity, hospital admission, travel abroad and organism variables were also excluded. Tabulations with basic confounders (sex and age) were undertaken for excluded cases who had data missing to assess whether the missing values were present at random.