All study participants underwent a brain MRI with a 3 T-MR750 General Electric scanner and an 8-channel head coil, with a recently described MRI protocol including a 3D T1-weighted MR image [42 (link)]. Freesurfer 7 was employed with the standard pipeline recon-all to automatically extract thickness and volume of 34 cortical regions for each hemisphere, and the volume of the subcortical regions caudate, putamen, globus pallidus, thalamus and cerebellum, divided into white and gray matter (WM, GM) [43 (link)]. All the segmentations performed by Freesurfer were visually inspected by a neuroradiologist, and images with inaccurate segmentations due to prominent movement artefacts (3 PSP-RS and 5 PSP-P patients) were excluded. The automated MRPI and MRPI 2.0 were calculated on 3D T1-weighted MR images using the previously described algorithm [29 (link)]. In 4 PSP-RS patients the algorithm failed and the MRPI and MRPI 2.0 were measured manually by an expert rater.
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