SCD Cartridges for CPB-Mediated SIRS

Example 3

Systemic Inflammatory Response Syndrome (SIRS) can occur in association with cardiopulmonary bypass (CPB) surgery, resulting in multiple organ dysfunction (MOD). Activated neutrophils have been implicated as major inciting factors in this process. This example describes in vitro and in vivo experiments that evaluate the effect of SCD cartridges for use during CPB surgery. The results demonstrate that the usage of SCD cartridges may disrupt the systemic leukocyte response during CPB surgery, leading to improved outcomes for CPB-mediated MOD.

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US11866730B2. Cytopheresis cartridges and use thereof (2024-01-09). SeaStar Medical, Inc. [US]. Inventors: H. David Humes [US], Deborah A. Buffington [US], Christopher J. Pino [US].

Patent 2024

Cardiopulmonary bypass Device Leukocyte Neutrophils Sirs

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Variable analysis

independent variables

Usage of SCD cartridges during cardiopulmonary bypass (CPB) surgery

dependent variables

Disruption of the systemic leukocyte response during CPB surgery
Improved outcomes for CPB-mediated multiple organ dysfunction (MOD)

control variables

Not explicitly mentioned

controls

Not explicitly mentioned

Annotations

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