The UK Biobank study is a prospective cohort included health, hospital-records and genetic data from more than 0.5 million participants [19 (link)]. UK Biobank has electronic signed consent from the study participants and ethical approval was obtained from Northwest Multi-center Research Ethics Committee. We used the imputed genotype dataset released by UK Biobank in July 2017. Subjects were excluded if the self-reported gender were inconsistent with the genetic gender, or were genotyped but not imputed or withdraw their consents.
DNA samples of all participants in the UK Biobank were genotyped using either the Affymetrix UK Biobank Axiom (825,927 markers) array or Affymetrix UK BiLEVE (807,411 markers) [20 (link)]. SNPs were imputed by IMPUTE2 against the reference panel of the, 1000 Genomes, UK10K projects, and Haplotype Reference Consortium. The details regarding these data are available elsewhere [21 (link)]. The current research has been performed under the Application Number 46478. The authors thank all UK Biobank participants and researchers who contributed or collected data.
DNA samples of all participants in the UK Biobank were genotyped using either the Affymetrix UK Biobank Axiom (825,927 markers) array or Affymetrix UK BiLEVE (807,411 markers) [20 (link)]. SNPs were imputed by IMPUTE2 against the reference panel of the, 1000 Genomes, UK10K projects, and Haplotype Reference Consortium. The details regarding these data are available elsewhere [21 (link)]. The current research has been performed under the Application Number 46478. The authors thank all UK Biobank participants and researchers who contributed or collected data.
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