Genome-Wide Association Study on Candidemia Susceptibility
The GWAS on candidemia susceptibility was previously described [48] . In short, upon quality control per SNP and sample, this GWAS was performed in a cohort of 161 candidemia cases and 152 disease-matched controls of European ancestry whose demographic and clinical characteristics have been previously described [53] . DNA was genotyped using Illumina HumanCoreExome-12 v1.0 and HumanCoreExome-24 v1.0 BeadChip SNP chips. Genotypes were imputed using the human reference consortium (HRC) panel [71] (link) using the Michigan imputation server [29] (link). In total, 5,426,313 SNPs were tested for disease association using Fisher’s exact test with PLINK v1.9 [84] (link). Detailed results and statistics can be found in Table 1.
Bruno M., Dewi I.M., Matzaraki V., ter Horst R., Pekmezovic M., Rösler B., Groh L., Röring R.J., Kumar V., Li Y., Carvalho A., Netea M.G., Latgé J.P., Gresnigt M.S, & van de Veerdonk F.L. (2020). Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways. Computational and Structural Biotechnology Journal, 19, 647-663.
Candidemia Chips European Genotypes Gwas Human Snps Susceptibility
Corresponding Organization : Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
Other organizations :
University Medical Center Groningen, University of Groningen, Centre for Individualised Infection Medicine, Helmholtz Centre for Infection Research, Center for Experimental and Clinical Infection Research, Medizinische Hochschule Hannover, University of Minho, University of Bonn, Institut Pasteur
Demographic and clinical characteristics of the 161 candidemia cases and 152 disease-matched controls of European ancestry
controls
No positive or negative controls were explicitly mentioned.
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