Clozapine (Abcam Biochemicals, Cambridge, U.K.) was dissolved in 0.1 N HCl supplemented with distilled water to the appropriate volume (final pH = 5.0–6.0). PCP HCl (Sigma-Aldrich), ondansetron (Tocris, U.K.), SB399885 (Tocris, U.K.), FPPQ, and CPPQ ((S)-1-[(3-chlorophenyl)sulfonyl]-4-(pyrrolidine-3-yl-amino)-1H-pyrrolo[3,2-c]quinolone)29 (link),67 (link) were dissolved in distilled water. All compounds were administrated in a volume of 1 mL/kg.
Zajdel P., Grychowska K., Mogilski S., Kurczab R., Satała G., Bugno R., Kos T., Gołębiowska J., Malikowska-Racia N., Nikiforuk A., Chaumont-Dubel S., Bantreil X., Pawłowski M., Martinez J., Subra G., Lamaty F., Marin P., Bojarski A.J, & Popik P. (2021). Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. Journal of Medicinal Chemistry, 64(18), 13279-13298.
Other organizations :
Jagiellonian University, Polish Academy of Sciences, Institut de Génomique Fonctionnelle, Institut des Biomolécules Max Mousseron
Solvent used to dissolve compounds (distilled water, 0.1 N HCl)
controls
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