Tigecycline Susceptibility of M. abscessus

Tigecycline (Tygacil^®, powder for IV infusion; Pfizer) was obtained from the Department of Pharmacy at Radboud University Medical Center (Nijmegen, the Netherlands). We obtained the M. abscessus subspecies abscessus CIP104536 type strain (synonym ATCC 19977) from the Pasteur Institute (Paris, France) and M. abscessus subspecies abscessus #21, a clinical isolate with smooth colony morphology,¹⁰ (link) from the University of Colorado Hospital Clinical Microbiology Laboratory. Identification of both isolates was confirmed by WGS; the raw sequence files (FASTQ) were archived in the NCBI Sequence Read Archive (project number PRJNA566387).

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Pearce C., Ruth M.M., Pennings L.J., Wertheim H.F., Walz A., Hoefsloot W., Ruesen C., Muñoz Gutiérrez J., Gonzalez-Juarrero M, & van Ingen J. (2020). Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo. Journal of Antimicrobial Chemotherapy, 75(7), 1889-1894.

Publication 2020

Tygacil®,

Clinical laboratory Iv infusion Powder Strain Tigecycline Tygacil

Corresponding Organization : Radboud University Nijmegen

Other organizations : Colorado State University

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Variable analysis

independent variables

Tigecycline (Tygacil®, powder for IV infusion; Pfizer)

dependent variables

Not explicitly mentioned

control variables

M. abscessus subspecies abscessus CIP104536 type strain (synonym ATCC 19977)
M. abscessus subspecies abscessus #21, a clinical isolate with smooth colony morphology

controls

Positive control: M. abscessus subspecies abscessus CIP104536 type strain (synonym ATCC 19977)
Negative control: M. abscessus subspecies abscessus #21, a clinical isolate with smooth colony morphology

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