Genetic Insights into Narcolepsy

Narcolepsy patients were selected as described, 98% of whom are predicted to be hypocretin deficient. The initial Caucasian sample was comprised of 807 cases and 1074 controls of mixed European ancestry; 415 cases and 753 controls were recruited from the US and Canada; 392 cases and 321 controls were recruited from European centers.
The Caucasian replication sample contained 718 individuals of whom 542 were recruited from the US and Canada (259 cases, 283 controls), and 176 from Europe (104 cases 72 controls). The Asian sample included 866 Japanese (433 cases, 433 controls) and 300 Koreans (128 cases, 172 controls). Finally, 277 African Americans were studied (133 cases, 144 controls). All subjects had given written informed consent approval.

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Hallmayer J., Faraco J., Lin L., Hesselson S., Winkelmann J., Kawashima M., Mayer G., Plazzi G., Nevsimalova S., Bourgin P., Hong S., Honda Y., Honda M., Högl B., Longstreth WT J.r., Montplaisir J., Kemlink D., Einen M., Chen J., Musone S.L., Akana M., Miyagawa T., Duan J., Desautels A., Erhardt C., Hesla P.E., Poli F., Frauscher B., Jeong J.H., Lee S.P., Ton T.G., Kvale M., Kolesar L., Dobrovolná M., Nepom G.T., Salomon D., Wichmann H.E., Rouleau G.A., Gieger C., Levinson D.F., Gejman P.V., Meitinger T., Young T., Peppard P., Tokunaga K., Kwok P.Y., Risch N, & Mignot E. (2009). Narcolepsy is strongly associated with the TCR alpha locus. Nature genetics, 41(6), 708-711.

Publication 2009

African americans Asian Caucasian European Hypocretin Japanese Koreans Narcolepsy Patients Replication

Corresponding Organization : Howard Hughes Medical Institute

Other organizations : University of California, San Francisco, Technical University of Munich, University of Bologna, Charles University, Hôpital Civil, Strasbourg, St. Vincent's Hospital, Tokyo Institute of Psychiatry, Innsbruck Medical University, University of Washington, Université de Montréal, The University of Tokyo, Northwestern University, Institute of Clinical and Experimental Medicine, Institute of Haematology and Blood Transfusion, Virginia Mason Medical Center, Scripps Research Institute, Helmholtz Zentrum München, University of Wisconsin–Madison, Kaiser Permanente

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Protocol cited in 11 other protocols

Variable analysis

independent variables

Population ancestry (Caucasian, Asian, African American)

dependent variables

Hypocretin deficiency

control variables

Written informed consent approval

controls

Positive control: Not explicitly mentioned.
Negative control: Not explicitly mentioned.

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