Clinical imaging data can capture the bone labyrinth structure but not or only partially reveal the membrane labyrinth structure. The microscopic CT data can show the structure of the bone labyrinthine and membrane labyrinthine, but the spatial orientation information of the inner ear is lacking, so it is necessary to indirectly determine the spatial direction through calibration.
Bone and membrane labyrinth models were extracted from clinical micro-CT images to obtain semicircular canal models that approximate the anatomy. The spatial orientation of the model was calibrated by establishing a standard three-dimensional coordinate system (22 (link)). There are individual differences in the spatial orientation of the inner ear. Therefore, this study established a standard three-dimensional coordinate system based on reconstructed magnetic resonance imaging (MRI) of 55 normal human inner ears to obtain a representative model of a membranous labyrinth (21 (link)). Firstly, bilateral inner ear and eyeball models were obtained by MRI image segmentation to generate statistical shape models, and the average model was derived as the standard model. Then, the standard three-dimensional space coordinate system was established with the total foot bifurcating point of the semicircular canal and the lower edge of the eyeball as the horizontal plane. Finally, the bone labyrinth models extracted from microscopic CT examination data were calibrated with the standard model. And then, the membrane labyrinth models were subjected to three-dimensional spatial transformation according to the calibration results to establish the spatial direction (18 (link)).
Bone and membrane labyrinth models were extracted from clinical micro-CT images to obtain semicircular canal models that approximate the anatomy. The spatial orientation of the model was calibrated by establishing a standard three-dimensional coordinate system (22 (link)). There are individual differences in the spatial orientation of the inner ear. Therefore, this study established a standard three-dimensional coordinate system based on reconstructed magnetic resonance imaging (MRI) of 55 normal human inner ears to obtain a representative model of a membranous labyrinth (21 (link)). Firstly, bilateral inner ear and eyeball models were obtained by MRI image segmentation to generate statistical shape models, and the average model was derived as the standard model. Then, the standard three-dimensional space coordinate system was established with the total foot bifurcating point of the semicircular canal and the lower edge of the eyeball as the horizontal plane. Finally, the bone labyrinth models extracted from microscopic CT examination data were calibrated with the standard model. And then, the membrane labyrinth models were subjected to three-dimensional spatial transformation according to the calibration results to establish the spatial direction (18 (link)).
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