Comparing Gastric Cancer Molecular Profiles

This study is a retrospective cohort comparative study of intestinal-type gastric cancer (IGC, well and moderately differentiated cell types) and diffuse-type gastric cancer (DGC, SRC type). We collected 8 total surgical samples: 5 IGC samples and 3 diffuse-type gastric cancer DGC samples. We compared expression profiles between clinically comparable samples using transcriptome resequencing data. We performed variant analysis and network analysis via the Ingenuity Pathway Analysis system (Qiagen).^{11 (link)}

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Park S.Y., Jeong S.H., Jung E.J., Ju Y.T., Jeong C.Y., Kim J.Y., Park T., Park J., Kim T.H., Park M., Yang J.W, & Lee Y.J. (2022). PHLPP1 Overexpression was Associated With a Good Prognosis With Decreased AKT Activity in Gastric Cancer. Technology in Cancer Research & Treatment, 21, 15330338211067063.

Publication 2022

Ingenuity Pathway Analysis system

Cell types Gastric cancer Intestinal Surgical Transcriptome

Corresponding Organization : Changwon National University

Other organizations : Gyeongsang National University Hospital

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Variable analysis

independent variables

Intestinal-type gastric cancer (IGC, well and moderately differentiated cell types)
Diffuse-type gastric cancer (DGC, SRC type)

dependent variables

Expression profiles

control variables

Clinically comparable samples

controls

No positive or negative controls were explicitly mentioned in the input protocol.

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