A structurally diverse dataset (n = 26), composed of compounds previously classified as glass formers (GFs) when prepared by melt-quenching, solvent evaporation, or spray-drying methods, was included in the study [5 (link),7 (link),8 (link),9 (link),10 (link),18 (link)]. Only compounds supplied in their free crystalline form (i.e., no salts, solvates, hydrates, etc.), as confirmed by DSC analysis, were used.
Metolazone was purchased from API Chemical (Hangzhou, China). Acetaminophen, bezafibrate, clofoctol, chlorpropamide, dimethyl sulfoxide, glibenclamide, glipizide, hydrocortisone, sodium hydroxide, sodium phosphate, sodium chloride, sulfamerazine, sulfathiazole, and tinidazole were supplied by Sigma-Aldrich (Steinheim, Germany). Aripiprazole, cinnarizine, clotrimazole, droperidol, d-salicin, fenofibrate, flurbiprofen, hydrochlorothiazide, ibuprofen, ketoconazole, ketoprofen, prednisone, and probucol were obtained from Toronto Research Chemical (Toronto, ON, Canada). Indapamide and procaine were purchased from Tokyo Chemical Co. Ltd. (Tokyo, Japan). Acetone was supplied by Merck (Darmstadt, Germany), ethanol by Solveco (Rosersberg, Sweden), and phosphorus pentoxide by VWR (Leuven, Belgium). All of the chemicals used in this study were of either pharmaceutical or analytical grade with a specified purity of ≥ 97%.
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