Statistics were performed using the SPSS 25.0 software (Statistical Package for Social Sciences, SPSS Inc, Chicago). We used three analyses of variance for repeated measures (rm-ANOVA) to examine if there was a difference between active HD-tDCS and the sham condition for our main region of interest (i.e., the prefrontal cortex). Data are reported as means and standard deviations. Mauchly's test was used to test for sphericity, and the Greenhouse–Geisser correction was applied if necessary. A p-value of < 0.05 was considered significant.
A three-way repeated-measures ANOVA was used to test for the effect of condition (active HD-tDCS vs. sham) x lead (Fp1, Fz, F3, F4, F7, F8, FC1, FC2) x frequency band (theta, alpha, beta) calculated in rsEEG absolute power (μV2).
For the calculation of the asymmetrical activity three repeated measures ANOVA for each frequency band (theta, alpha, beta) were conducted to test whether this activity changed from pre to posttest for the two groups (HD-tDCS vs. Sham).
To compute phase synchronization, we extracted the PLV using the method described by Lachaux et al. (1999) (link) and calculated the difference in symmetry between the electrode pairs that are part of the frontal region (Fz, Fp1, F3, F4, F7, F8, FC1, FC2) using a customized MATLAB script. We measured the connectivity between the electrodes using the Phase Locking Value (PLV). We conducted separate repeated-measures ANOVAs for the PLV of each chosen frontal electrode pair over Time (pretest vs posttest) with group (HD-tDCS vs Sham) as a between subjects factor.
A three-way repeated-measures ANOVA was used to test for the effect of condition (active HD-tDCS vs. sham) x lead (Fp1, Fz, F3, F4, F7, F8, FC1, FC2) x frequency band (theta, alpha, beta) calculated in rsEEG absolute power (μV2).
For the calculation of the asymmetrical activity three repeated measures ANOVA for each frequency band (theta, alpha, beta) were conducted to test whether this activity changed from pre to posttest for the two groups (HD-tDCS vs. Sham).
To compute phase synchronization, we extracted the PLV using the method described by Lachaux et al. (1999) (link) and calculated the difference in symmetry between the electrode pairs that are part of the frontal region (Fz, Fp1, F3, F4, F7, F8, FC1, FC2) using a customized MATLAB script. We measured the connectivity between the electrodes using the Phase Locking Value (PLV). We conducted separate repeated-measures ANOVAs for the PLV of each chosen frontal electrode pair over Time (pretest vs posttest) with group (HD-tDCS vs Sham) as a between subjects factor.
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