Six individuals were included in this study: three control patients (A, B, and C), hereafter referred to as controls, with diagnosed dyspeptic disorders who did not receive any treatment and three patients (D, E, and F) that had either a gastric or duodenal ulcer and were treated twice a day for seven days with metronidazole 400 mg, clarithromycin 250 mg, and omeprazole 20 mg (Supplementary Table S6 for subject info). None of the patients had received any antibiotic treatment within four weeks prior to the start of the study and during the four-year course of the study no other antimicrobial treatment was allowed. The patients did not receive any diet restrictions or recommendations before inclusion into the study. A throat swab and a fecal sample were collected from each subject one day before treatment, immediately after (Control A: 13 days, control B: 12 days, control C: 13 days, patient D: 12 days, patient E: 8 days, patient F: day 10) and one and four years after treatment. All samples were stored at −70°C until analyzed. This material was part of a larger longitudinal cohort study where the aim was to study eradication of H. pylori using a common treatment regimen [11] (link).
Free full text: Click here