Evaluation of Antidepressant Compounds

Fluoxetine (#H6995, Bosche Scientific), citalopram (#C505000, Toronto Research Chemicals), paroxetine (#2141, Tocris), fluvoxamine (#1033), venlafaxine (#2917, Tocris), reboxetine (#1982, Tocris), imipramine (#I7379-5G, Sigma–Aldrich), clomipramine (#C7291, Sigma–Aldrich), desipramine (#3067, Tocris), phenelzine (#P6777, Sigma–Aldrich), rolipram (#R6520, Sigma–Aldrich), ketamine (#3131, Tocris), 2R, 6R-Hydroxynorketamine and 2S, 6S-Hydroxynorketamine (#6094 and #6095, respectively, Tocris), carbamazepine (#4098, Tocris), chlorpromazine (#C8138, Sigma–Aldrich), flupenthixol (#4057, Tocris), and pimozide (#0937, Tocris) were investigated in this study. The compounds were dissolved in dimethyl sulfoxide (DMSO) that was also used as a vehicle in all the experiments. Concentrations tested (Table 1) were selected based on earlier in vitro studies from our research group (Fred et al., 2019 (link); Casarotto et al., 2021 (link)) and other laboratories (Johansen et al., 2015 (link)).

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Fred S.M., Kuivanen S., Ugurlu H., Casarotto P.C., Levanov L., Saksela K., Vapalahti O, & Castrén E. (2022). Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Frontiers in Pharmacology, 12, 755600.

Publication 2021

fluvoxamine venlafaxine reboxetine imipramine clomipramine desipramine phenelzine rolipram ketamine carbamazepine chlorpromazine flupenthixol pimozide

Carbamazepine Chlorpromazine Citalopram Clomipramine Desipramine Dimethyl sulfoxide Fluoxetine Flupenthixol Fluvoxamine Imipramine Ketamine Paroxetine Phenelzine Pimozide Reboxetine Rolipram Venlafaxine

Corresponding Organization : University of Helsinki

Other organizations : Helsinki University Hospital

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Variable analysis

independent variables

Fluoxetine
Citalopram
Paroxetine
Fluvoxamine
Venlafaxine
Reboxetine
Imipramine
Clomipramine
Desipramine
Phenelzine
Rolipram
Ketamine
2R, 6R-Hydroxynorketamine
2S, 6S-Hydroxynorketamine
Carbamazepine
Chlorpromazine
Flupenthixol
Pimozide

dependent variables

Not explicitly mentioned

control variables

Dimethyl sulfoxide (DMSO) used as a vehicle in all experiments

controls

Positive controls: Not specified
Negative controls: Not specified

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