Forty-eight mice xenografted with mixed UM fragments from patient case 6 and 7 (Additional file 1 : Table S1) were equally grouped in to four groups according to the treatment protocols: control with 100 μl 0.9 % saline S.C. per week (n = 12) [35 (link)], AI (Letrozole; Femara® were prepared in 0.3 % hydroxypropylcellulose; mice were injected S.C. five times per week with Letrozole 10 μg per mouse per day; Novartis, Switzerland) (n = 12) [36 (link)], GnRHa (Leuprorelin acetate S.C. 10 mg/kg per week; LEUPLIN®DEPOT 3.75 mg S.C. Injection, Takeda, Japan) (n = 12) [37 (link)], and SERM (Raloxifene hydrochloride, 0.1 μg S.C. per day; Sigma-Aldrich, US) [32 (link)].
Laparotomic examination was performed and these mice were sacrificed 3 weeks after the xenograft procedures.
Laparotomic examination was performed and these mice were sacrificed 3 weeks after the xenograft procedures.
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