Image-Guided Tumor Resection and Lymphatic Mapping

For image-guided surgery, 48 h after intravenous injection of IR808-DOTA
(100 μL, 10 μg) into tumor-bearing nude mice, tumor resection
was guided by NIRF imaging.
For lymphatic mapping, tumor-bearing
mice were intradermally injected with IR808-DOTA (10 μL, 1 μg)
on the hind footpad. Lymphatic drainage
and sentinel lymph node imaging were carried out 30 min later.

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Zhu J., Jiang Y., Pan X., Xu K., Niu W., Lv Y., Li C., Wang Y., Xue Z., Lei P, & He Y. (2023). In Vivo Evaluation of a Gallium-68-Labeled Tumor-Tracking Cyanine Dye for Positron Emission Tomography/Near-Infrared Fluorescence Carcinoma Imaging, Image-Guided Surgery, and Photothermal Therapy. ACS Omega, 8(6), 6067-6077.

Publication 2023

Dota Image guided surgery Nude mice Sentinel lymph node Tumor

Corresponding Organization : Huazhong University of Science and Technology

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Variable analysis

independent variables

Intravenous injection of IR808-DOTA (100 μL, 10 μg) into tumor-bearing nude mice
Intradermal injection of IR808-DOTA (10 μL, 1 μg) on the hind footpad of tumor-bearing mice

dependent variables

Tumor resection guided by NIRF imaging
Lymphatic drainage and sentinel lymph node imaging

control variables

Time after injection (48 h for image-guided surgery, 30 min for lymphatic mapping)
Tumor-bearing nude mice

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

Annotations

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