IgE Antibodies Against Na-GST-1 in Helminth-Endemic Region
Prior to initiation of the Phase 1 trials of Na-GST-1/Alhydrogel, stored serum samples collected from children and adults living in Americaninhas were tested for IgE antibodies against Na-GST-1. These sera had been collected from individuals enrolled in previously reported clinical studies of helminth epidemiology, treatment and transmission [24 (link)]. IgE antibody levels against Na-GST-1 were measured by using the fluoroenzyme immunoassay (ImmunoCAP 250; Phadia, Uppsala Sweden) at the Johns Hopkins Dermatology, Allergy and Clinical Immunology Reference Laboratory. IgE levels greater than 0.1 kU/L (0.24 ng/dL) were considered clinically significant.
Diemert D.J., Freire J., Valente V., Fraga C.G., Talles F., Grahek S., Campbell D., Jariwala A., Periago M.V., Enk M., Gazzinelli M.F., Bottazzi M.E., Hamilton R., Brelsford J., Yakovleva A., Li G., Peng J., Correa-Oliveira R., Hotez P, & Bethony J. (2017). Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLoS Neglected Tropical Diseases, 11(5), e0005574.
AdultsAlhydrogel Allergy Antibody ige Children Clinical laboratory HelminthImmunoassay Sera Transmission
Corresponding Organization : George Washington University
Other organizations :
Fundação Oswaldo Cruz, Universidade Federal de Minas Gerais, Texas Children's Hospital, Baylor College of Medicine, Sabin Vaccine Institute, Johns Hopkins Medicine, Johns Hopkins University
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