Chitosan-PEG Crosslinked Hydrogels

Example 2

This example also utilizes amine functional groups from chitosan and succinimide functional groups from succinimide terminated PEG. In this example, a free-flowing composition is formed by mixing the chitosan and PEG, for example, in a volume ratio ranging from 1:1 to 1:0.5 (Chitosan:PEG).

In alternative embodiments, the chitosan portion of the mixture may comprise modified chitosan in addition to or in place of the chitosan. Examples of modified chitosan include carboxymethylchitosan crosslinked with chitosan (high and/or low molecular weight), thiolated chitosan, and thiol-chitosan-PEG copolymer.

Such mixtures may be solubilized in pH 4 solution, after which crosslinking is effected by combination with a pH 9 buffer.

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US11878092B2. Medical compositions based on crosslinkable hydrophilic polymers (2024-01-23). Boston Scientific Scimed Inc. [US]. Inventors: Lauren Lydecker [US], Jennifer Whelehan [US].

Patent 2024

Amine Buffer Carboxymethylchitosan Chitosan Polymers Succinimide Thiol

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Variable analysis

independent variables

Chitosan to PEG volume ratio (ranging from 1:1 to 1:0.5)
Use of modified chitosan (e.g., carboxymethylchitosan crosslinked with chitosan, thiolated chitosan, thiol-chitosan-PEG copolymer)

dependent variables

Formation of a free-flowing composition

control variables

PH of the solution (pH 4 for solubilization, pH 9 for crosslinking)

controls

Positive control: Mixing chitosan and PEG in the specified volume ratio range
Negative control: Not specified

Annotations

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