Analyzing Immune Biomarkers in NHANES

Peripheral blood samples of the NHANES participants were analyzed at the Mobile Examination Centers (MEC) using a Beckman Coulter HMX Hematology Analyzer. Lymphocyte, neutrophil, monocyte, and platelet counts were measured via complete blood count, and were presented as ×10³ cells/μL. The SII and SIRI levels were calculated using the following formulas: platelet count × neutrophil count/lymphocyte count, monocyte count × neutrophil count/lymphocyte count, respectively. These values were expressed as ×10³ cells/μL based on previous studies (4 (link), 14 (link), 15 (link)). SII and SIRI were considered as exposure variables in this study.

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Ma R., Cui L., Cai J., Yang N., Wang Y., Chen Q., Chen W., Peng C., Qin H., Ding Y., Wang X., Yu Q, & Shi Y. (2024). Association between systemic immune inflammation index, systemic inflammation response index and adult psoriasis: evidence from NHANES. Frontiers in Immunology, 15, 1323174.

Publication 2024

HMX Hematology Analyzer

Corresponding Organization : Shanghai Tenth People's Hospital

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Variable analysis

independent variables

SII (platelet count × neutrophil count/lymphocyte count)
SIRI (monocyte count × neutrophil count/lymphocyte count)

dependent variables

Lymphocyte count
Neutrophil count
Monocyte count
Platelet count

control variables

Not explicitly mentioned

Annotations

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