Solvent-Assisted Mechanosynthesis of Meloxicam-Tartaric Acid Co-Crystals

The co-crystals were obtained by solvent-assisted mechanosynthesis as follows: the mixtures of a selected mole fraction of meloxicam and tartaric acid were mixed and ground for 5 to 10 min at room temperature using a mortar and pestle to obtain complete homogenization. After that, approximately 0.06 mL methanol was addedadded, and the grinding was continued until the complete evaporation of the solvent (Figure 1). After preparation, the mixtures were kept in a desiccator until they were studied.

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Macasoi C., Meltzer V., Stanculescu I., Romanitan C, & Pincu E. (2024). Binary Mixtures of Meloxicam and L-Tartaric Acid for Oral Bioavailability Modulation of Pharmaceutical Dosage Forms. Journal of Functional Biomaterials, 15(4), 104.

Publication 2024

Corresponding Organization :

Other organizations : University of Bucharest, Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering, National Institute for Research and Development in Microtechnologies

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Variable analysis

independent variables

Mole fraction of meloxicam and tartaric acid

dependent variables

Not explicitly mentioned

control variables

Grinding time (5 to 10 minutes)
Room temperature
Methanol addition (approximately 0.06 mL)

controls

No positive or negative controls were explicitly mentioned in the provided information.

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