Mouse Strains for Diabetes Research

Female NOD/ShiLtJ (NOD), NOD.CB17-Prkdc^scid/J (NOD-scid), B6.NOD-(D17Mit21-D17Mit10)/LtJ (B6^g7), and DBA/2J (DBA) mice were from The Jackson Laboratory. B6.G9C8 mice, transgenic for T-cell receptor (TCR) derived from InsB^15–23-specific CD8⁺ T-cell clone G9C8, and H-2K^d MHC allele (19 (link)) were provided by Dr. A. Chervonsky (University of Chicago, Chicago, IL).

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Radichev I.A., Maneva-Radicheva L.V., Amatya C., Parker C., Ellefson J., Wasserfall C., Atkinson M., Burn P, & Savinov A.Y. (2014). Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development. Diabetes, 63(10), 3470-3482.

Publication 2014

Female NOD/ShiLtJ NOD.CB17-Prkdcscid/J B6.NOD-(D17Mit21-D17Mit10)/LtJ (B6g7),

Allele Cd8 t cell Clone Dba mice Female Mice Scid T cell receptor Transgenic

Corresponding Organization : Sanford Research

Other organizations : University of Florida

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Variable analysis

independent variables

Genotype of mice: Female NOD/ShiLtJ (NOD), NOD.CB17-Prkdcscid/J (NOD-scid), B6.NOD-(D17Mit21-D17Mit10)/LtJ (B6g7), and DBA/2J (DBA)
Transgenic T-cell receptor (TCR) derived from InsB15–23-specific CD8+ T-cell clone G9C8 in B6.G9C8 mice

dependent variables

Not explicitly mentioned

control variables

H-2Kd MHC allele in B6.G9C8 mice

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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