We downloaded RNA-seq BAM files of 6,309 patient samples (including 6,083 primary tumor samples and 226 metastasis samples) across 20 TCGA cancer types and their related 564 non-tumor tissue samples (if available)(10 (link)) from the UCSC Cancer Genomics Hub (CGHub, https://cghub.ucsc.edu/). Included were bladder urothelial carcinoma (BLCA), brain lower grade glioma (LGG), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), colon adenocarcinoma (COAD), cutaneous melanoma (SKCM), glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), ovarian serous cystadenocarcinoma (OV), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA), and uterine corpus endometrioid carcinoma (UCEC). We also downloaded 739 BAM files of Cancer Cell Line Encyclopedia (CCLE) cell lines (12 (link)) from CGHub. In addition, we obtained the RNA-seq files of 531 samples from another three independent studies, including lung adenocarcinoma (13 (link)), clear-cell renal cell carcinoma (14 (link)), and glioblastomas (15 ). In total, the current TANRIC release includes RNA-seq data from 8,143 samples (1,142 billion reads).