Comprehensive Metabolic Gene Pathway Analysis

Metabolism-related genes were identified from the Molecular Signatures Database (MSigDB) (https://www.gsea-msigdb.org/gsea/msigdb/index.jsp) (Subramanian et al., 2005 (link)). Overall, 12 metabolic gene sets were obtained, which included the reactome pyrimidine catabolism, reactome pentose phosphate pathway, reactome purine catabolism, reactome metabolism of amino acids and derivatives, reactome citric acid/TCA cycle and respiratory electron transport, reactome glycogen metabolism, reactome metabolism of lipids, reactome fatty acid metabolism, reactome glutamate and glutamine metabolism, reactome pyruvate metabolism, reactome glucose metabolism, and reactome metabolism of nucleotides.