A rheumatologist independently evaluated laboratory findings, clinico-radiological data and other necessary examinations and re-assessed the CTD diagnoses. Patients were included in the IIM subgroup if they fulfilled either (I) the probable or definite European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and their Major Subgroups (2 (link)), or (II) the Connor’s criteria for ASyS (18 (link)). Other CTD diagnoses were confirmed by using the current International classification criteria of each disease (19 (link)-27 (link)). Eight patients with dry eyes, dry mouth, and Sjögren’s-syndrome-related antigen A/B (SSA/SSB) antibodies were included to SjS subgroup as highly probable SjS, without objective tests for dryness of mouth or eyes, but with multiple signs and symptoms supporting the diagnosis. Twenty-three patients with autoantibodies or clinical features of CTD without meeting the criteria for any specific autoimmune disease were included as UCTD (28 (link)).
Protocol detail
Rheumatologist-Assessed CTD Diagnosis Criteria
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Adult
Antibodies
Antigen
Autoantibodies
Autoimmune disease
Diagnosis
Dry eyes
Dryness mouth
European
Examinations
Eyes
Idiopathic inflammatory myopathies
Patients
Radiological
Rheumatologist
Syndrome
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Variable analysis
independent variables
- Rheumatologist's independent evaluation of laboratory findings, clinico-radiological data, and other necessary examinations
- Re-assessment of CTD diagnoses by the rheumatologist
- Inclusion of patients in the IIM subgroup
- Confirmation of other CTD diagnoses
- Inclusion of patients with dry eyes, dry mouth, and SSA/SSB antibodies in the SjS subgroup
- Inclusion of patients with autoantibodies or clinical features of CTD without meeting the criteria for any specific autoimmune disease in the UCTD subgroup
- Fulfillment of either (I) the probable or definite EULAR/ACR Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and their Major Subgroups, or (II) the Connor's criteria for ASyS for inclusion in the IIM subgroup
- Use of the current International classification criteria of each disease for confirmation of other CTD diagnoses
- Multiple signs and symptoms supporting the diagnosis of Sjögren's syndrome for inclusion in the SjS subgroup without objective tests for dryness of mouth or eyes
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