Dissolving Dinaciclib and MK-2206 for Research

Dinaciclib and MK-2206 were provided by Merck and Co. (Boston, MA). Dinaciclib was dissolved in 20% hydroxypropyl-β-cyclodextrin (HPBCD; Sigma, St. Louis, MO) (18 (link)). MK-2206 was dissolved in 0.5% methanol, 0.1% Tween-80.

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Hu C., Dadon T., Chenna V., Yabuuchi S., Bannerji R., Booher R., Strack P., Azad N., Nelkin B.D, & Maitra A. (2015). Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models. Molecular cancer therapeutics, 14(7), 1532-1539.

Publication 2015

Dinaciclib MK-2206 HPBCD

Cyclodextrin Dinaciclib Hydroxypropyl Methanol Mk 2206 Tween 80

Corresponding Organization : The University of Texas MD Anderson Cancer Center

Other organizations : MSD (United States)

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Variable analysis

independent variables

Dinaciclib
MK-2206

dependent variables

Not explicitly mentioned

control variables

Concentration of Dinaciclib (20% hydroxypropyl-β-cyclodextrin (HPBCD))
Concentration of MK-2206 (0.5% methanol, 0.1% Tween-80)

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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