The gait data of freely moving rats were recorded using the CatWalk System (Noldus Information Technology, Netherlands). A compliant run was defined as a run without interruptions or hitches; all limb data were clearly classified. At least one compliant run was collected and analyzed using computer software (CatWalk XT 10) for each rat [18 (link)]. The nanoindentation experiments were performed using a Piuma Nanoindenter (Optics11, the Netherlands), which can locally detect cartilage mechanical properties via indentation using a previously described method [19 (link),20 ]. Ten regions were selected for the indentation test in each sample, including five each for the medial and lateral plateau cartilages.
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Gait and Cartilage Mechanics Analysis
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Cartilages
Corresponding Organization : Shanxi Medical University
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Variable analysis
independent variables
- Cartilage mechanical properties
- Gait data of freely moving rats
- Compliant run (without interruptions or hitches)
- Clearly classified limb data
- Positive control: Not explicitly mentioned.
- Negative control: Not explicitly mentioned.
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