Synthesis of Novel Anti-Bacterial Compounds

All bacterial strains were from Prof. Jolanta Łukasiewicz (Polish Academy of Sciences, Wrocław, Poland). Reagents and apparatus that were used in the work were described in detail in our earlier works in this field.
The synthesis of new compounds from the α-hydroxy phosphonate derivatives, similarly to other compounds studied by us in previous works, may determine a new alternative to the commonly used antibiotics in clinical infections. This chemical and biological activity is related to two kinds of specific substituents in their structure R1 and R2 (see Scheme 1). Dysfunction of bacterial membranes containing different lengths of LPS in model bacterial strains is an ideal model to assess the effectiveness of these compounds in relation to the antibiotics used by a specific enzyme Fpg of modified bacterial DNA (Labjot, New England Biolabs, Ipswich, MA, USA).