The SERVE-HF trial investigated the effects of adding adaptive servo ventilation (ASV) (AutoSet CS, ResMed) vs. guideline-based medical treatment alone on survival and cardiovascular outcomes in patients with HFrEF and predominantly CSA. The SERVE-HF trial was an international, multicenter, randomized, parallel-group and event-driven study (clinical trial identifier: NCT00733343). Information about the trial design, procedures, outcomes, and results have been previously reported [5 (link), 6 (link)]. The trial was conducted in accordance with the Good Clinical Practice guidelines and principles of the 2002 Declaration of Helsinki. Institutional Review Board approval was obtained, and all patients signed an informed consent form to participate in the study.
de Gonzalo-Calvo D., Martinez-Camblor P., Belmonte T., Barbé F., Duarte K., Cowie M.R., Angermann C.E., Korte A., Riedel I., Labus J., Koenig W., Zannad F., Thum T, & Bär C. (2023). Circulating miR-133a-3p defines a low-risk subphenotype in patients with heart failure and central sleep apnea: a decision tree machine learning approach. Journal of Translational Medicine, 21, 742.
Other organizations :
Hospital Universitari Arnau de Vilanova, Biomedical Research Institute of Lleida, Dartmouth College, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Université de Lorraine, Inserm, Guy's and St Thomas' NHS Foundation Trust, Royal Brompton Hospital, Universitätsklinikum Würzburg, Medizinische Hochschule Hannover, Technical University of Munich, Deutsches Herzzentrum München, French Clinical Research Infrastructure Network
Addition of adaptive servo ventilation (ASV) (AutoSet CS, ResMed)
dependent variables
Survival
Cardiovascular outcomes
control variables
Guideline-based medical treatment alone
controls
Positive control: Guideline-based medical treatment alone
Negative control: Not explicitly mentioned
Annotations
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