SOR, PND1186 and PF431396 (Selleck Chemicals, Houston, TX, USA) and TAE226 (kindly provided by Novartis Pharm) were dissolved in dimethyl sulfoxide and stored at − 80 °C until time of use. HCC cells were exposed to different concentration of drugs for different times as detailed in the results. Cells were lentivirally silenced for FAK as already described [13 (link)].
Romito I., Porru M., Braghini M.R., Pompili L., Panera N., Crudele A., Gnani D., De Stefanis C., Scarsella M., Pomella S., Levi Mortera S., de Billy E., Conti A.L., Marzano V., Putignani L., Vinciguerra M., Balsano C., Pastore A., Rota R., Tartaglia M., Leonetti C, & Alisi A. (2021). Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects. Journal of Experimental & Clinical Cancer Research : CR, 40, 364.
Other organizations :
Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Vita-Salute San Raffaele University, University Hospital Brno, St. Anne's University Hospital Brno, University of L'Aquila
Different concentration of drugs (SOR, PND1186, PF431396, TAE226)
Different exposure times of drugs
dependent variables
Measured outcomes in HCC cells
control variables
HCC cells were lentivirally silenced for FAK
controls
Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned
Annotations
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