Seventeen (4 women and 13 men, age 64 ± 7.21 years, mean ± SD) patients with de-novo parkinsonian syndrome consecutively referred to a Neurology Unit to evaluate PD over a 24-month interval (from June 2012 to June 2014) were recruited in this dataset. More details about clinical evaluation can be found in Ref.63 (link). Seventeen healthy controls (5 women and 12 men, age 64 ± 7 years, mean ± SD) with no history of neurological diseases and normal neurological examination were recruited as controls. No significant difference in age (p = 0.95 at t-test) and gender (p = 0.70 at χ2-test) was found between the two groups.
All subjects underwent high-resolution 3D T1-weighted imaging on a 1.5 T MR scanner system (Magnetom Avanto, software version Syngo MR B17, Siemens, Erlangen-Germany) equipped with a 12-element matrix radiofrequency head coil and SQ-engine gradients. The SQ-engine gradients had a maximum strength of 45 mT/m and a slew rate of 200 T/m/s. T1-weighted MR images were acquired with an axial high resolution 3D MPRAGE sequence with TR = 1900 ms, TE = 3.44 ms, TI = 1100 ms, flip angle = 15°, slice thickness = 0.86 mm, field of view (FOV) = 220 mm × 220 mm, matrix size = 256 × 256, number of excitations (NEX) = 2, number of slices = 176.
All subjects underwent high-resolution 3D T1-weighted imaging on a 1.5 T MR scanner system (Magnetom Avanto, software version Syngo MR B17, Siemens, Erlangen-Germany) equipped with a 12-element matrix radiofrequency head coil and SQ-engine gradients. The SQ-engine gradients had a maximum strength of 45 mT/m and a slew rate of 200 T/m/s. T1-weighted MR images were acquired with an axial high resolution 3D MPRAGE sequence with TR = 1900 ms, TE = 3.44 ms, TI = 1100 ms, flip angle = 15°, slice thickness = 0.86 mm, field of view (FOV) = 220 mm × 220 mm, matrix size = 256 × 256, number of excitations (NEX) = 2, number of slices = 176.
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