Streptozotocin-Induced Diabetes in Rats

After overnight fasting, diabetes mellitus was induced in animals with a single intraperitoneal injection (i.p.) of streptozotocin (STZ) at 55 mg/kg prepared in a 0.01M citrate buffer of 4.5 pH [21 (link)]. On the third day after STZ injection, a drop of blood was drawn from the tail vein of each rat, and the blood glucose levels were estimated using a glucometer (ACCUCHECK Active Glucose Monitor, Roche, Germany). Rats with blood glucose levels of ≥250 mg/dL were considered diabetic and underwent surgical wounding.

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Fatima F., Aleemuddin M., Ahmed M.M., Anwer M.K., Aldawsari M.F., Soliman G.A., Mahdi W.A., Jafar M., Hamad A.M, & Alshehri S. (2022). Design and Evaluation of Solid Lipid Nanoparticles Loaded Topical Gels: Repurpose of Fluoxetine in Diabetic Wound Healing. Gels, 9(1), 21.

Publication 2022

ACCUCHECK Active Glucose Monitor

Animals Blood Blood glucose Buffer Citrate Diabetes mellitus Glucose Intraperitoneal injection Rats Streptozotocin Tail Vein

Corresponding Organization : Prince Sattam Bin Abdulaziz University

Other organizations : MNR Medical College and Hospital, Cairo University, King Saud University, Imam Abdulrahman Bin Faisal University

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Variable analysis

independent variables

Streptozotocin (STZ) injection at 55 mg/kg

dependent variables

Blood glucose levels

control variables

Overnight fasting
0.01M citrate buffer of 4.5 pH

controls

Positive control: Animals with blood glucose levels ≥250 mg/dL were considered diabetic and underwent surgical wounding.

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