For all studies, we recalibrated serum creatinine values to the standardized creatinine measurements using the Roche enzymatic method (Roche-Hitachi P-Module instrument with Roche Creatininase Plus assay, Hoffman-La Roche, Ltd., Basel, Switzerland) at the Cleveland Clinic Research Laboratory (Cleveland, OH) as previously described (29 (link), 30 (link)). We compared new equations to the MDRD Study equation, given by: estimated GFR = 175 × standardized Scr −1.154 × age−0.203 × 1.212 [if black] × 0.742 [if female], where GFR is expressed as mL/min/1.73 m2 of body surface area41 and Scr is expressed in mg/dL(4 (link)).
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Standardized Creatinine Recalibration Protocol
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Other organizations : National Institutes of Health, Johns Hopkins University, Cleveland Clinic, University of Pennsylvania, University of Utah
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Variable analysis
independent variables
- Standardized serum creatinine (S_cr) values
- Estimated glomerular filtration rate (GFR)
- Roche enzymatic method (Roche-Hitachi P-Module instrument with Roche Creatininase Plus assay, Hoffman-La Roche, Ltd., Basel, Switzerland) at the Cleveland Clinic Research Laboratory (Cleveland, OH) used to recalibrate serum creatinine values to the standardized creatinine measurements
- MDRD Study equation to compare new equations: estimated GFR = 175 × standardized S_cr ^-1.154 × age^-0.203 × 1.212 [if black] × 0.742 [if female], where GFR is expressed as mL/min/1.73 m^2 of body surface area and S_cr is expressed in mg/dL
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