Coronary vascular function was quantified in all patients using a whole-body PET/computed tomography scanner (PET/CT Discovery RX or STE LightSpeed 64, GE Healthcare, Milwaukee, WI). Myocardial blood flow (MBF, in mL/min/g) was measured at rest and during maximal hyperemia by a standard intravenous infusion of adenosine, dipyridamole or regadenoson using either 13N-ammonia or 82Rubidium as the flow tracers, as described previously.14 (link) The image acquisition and post processing techniques for quantification of myocardial blood flow (MBF) and flow reserve did not change over the study period. Previous studies have demonstrated that equivalence of dipyridamole, regadenoson, and adenosine as vasodilators for myocardial perfusion imaging and quantitative myocardial blood flow.15 (link), 16 (link) Furthermore, the use of different vasodilator stress agents has not affected the value of quantitative myocardial blood flow by PET for risk stratification.15 (link), 17 (link)-19 (link) The heart rate, blood pressure, and 12-lead electrocardiogram were recorded at baseline and every minute during and after the vasodilator infusion.
Protocol detail
Quantitative Myocardial Blood Flow Assessment
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Adenosine
Ammonia
Blood flow
Blood pressure
Body
Computed tomography scanner
Coronary vascular
Dipyridamole
Electrocardiogram
Heart rate
Hyperemia
Intravenous infusion
Myocardial
Patients
Pet ct
Post techniques
Regadenoson
Vasodilator
Corresponding Organization :
Other organizations : Harvard University, Brigham and Women's Hospital, University of Alabama at Birmingham, Massachusetts General Hospital, New York University
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Variable analysis
independent variables
- Vasodilator stress agents (adenosine, dipyridamole, or regadenoson)
- Myocardial blood flow (MBF) at rest and during maximal hyperemia
- The image acquisition and post processing techniques for quantification of myocardial blood flow (MBF) and flow reserve did not change over the study period.
- The heart rate, blood pressure, and 12-lead electrocardiogram were recorded at baseline and every minute during and after the vasodilator infusion.
- Previous studies have demonstrated that equivalence of dipyridamole, regadenoson, and adenosine as vasodilators for myocardial perfusion imaging and quantitative myocardial blood flow.
- Not explicitly mentioned.
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