UK Biobank Cohort and MRI Study

UK Biobank is a prospective study of over 500 000 healthy volunteers aged 40–69 years recruited across the UK between 2006 and 2010.11 (link) About 9 million individuals were invited to join, of whom 5.5% participated in the baseline assessment.12 (link) Phenotypic data were collected through questionnaires and physical examinations. A subset of 100 000 individuals are also participating in the MRI Study, and approximately 40 000 brain MRIs were available at the time of this analysis. These participants were selected on the basis of travelling distance from the imaging centre and not clinical information. All MRIs were performed on one of the two identical Skyra 3.0T scanners (Siemens Medical Solutions, Germany). Identical acquisition parameters and quality control was used for all scans.13 (link) In October 2020, whole-exome sequences of 200 632 UK Biobank participants were released and all were included here. This analysis was performed under UK Biobank application number 36509.