Example 1
Ultrapure water was taken in a compounding vessel and arginine was added and stirred. Propylene glycol was added to the solution and stirred. pH of the solution was adjusted to 11±0.5 by the addition of sodium hydroxide solution. Then the bulk solution was cooled to 2° C. to 8° C. Levothyroxine sodium was added and stirred till a clear solution was obtained, while maintaining the temperature at 5±3° C. The solution was filtered, followed by filling into suitable containers.
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