To synthesize CeO2-ZIF-8-HA: Dissolve zinc nitrate, dimethylimidazole and QT separately. Add CeO2 and QT to the dimethylimidazole solution first and mix well with it, then add zinc nitrate solution to the mixed solution slowly drop by drop. The solution was stirred at room temperature for about half an hour, and the precipitate was washed by centrifugation to obtain C/Q@ZIF-8. The micelle surface was then modified with HA by EDC/NHS cross-linking reaction to obtain the C/Q@ZIF-8-HA with CD44 activity targeting.
To synthesize CeO2@ZIF-8-HA: Briefly, dissolve zinc nitrate and dimethylimidazole separately. Add CeO2 to the dimethylimidazole solution and mix it well, then add zinc nitrate solution to the mixed solution slowly drop by drop. The solution was stirred at room temperature and reacted for about half an hour, and the precipitate was washed by centrifugation to get CeO2@ZIF-8. The micelle surface was then modified with HA by EDC/NHS cross-linking reaction to obtain the CeO2@ZIF-8-HA with CD44 activity targeting.
To synthesize CeO2@ZIF-8-HA: Briefly, dissolve zinc nitrate and dimethylimidazole separately. Add CeO2 to the dimethylimidazole solution and mix it well, then add zinc nitrate solution to the mixed solution slowly drop by drop. The solution was stirred at room temperature and reacted for about half an hour, and the precipitate was washed by centrifugation to get CeO2@ZIF-8. The micelle surface was then modified with HA by EDC/NHS cross-linking reaction to obtain the CeO2@ZIF-8-HA with CD44 activity targeting.
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