IPF Lung Tissue Procurement and Use

Deidentified patient samples were obtained by our tissue procurement service (Bionet) under a waiver of informed consent from the University of Minnesota IRB (no. 1504M68341). Fresh IPF lungs were obtained at the time of lung transplantation, and control lung tissue was obtained by VATS biopsy or lobectomy. Animal protocols were approved and conducted in accordance with the University of Minnesota IACUC regulations (approval no. 1706-34890A).

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Yang L., Gilbertsen A., Xia H., Benyumov A., Smith K., Herrera J., Racila E., Bitterman P.B, & Henke C.A. (2023). Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway. JCI Insight, 8(4), e163820.

Publication 2023

Animal Biopsy Iacuc Lung Lung transplantation Patient Tissue Tissue procurement Vats

Corresponding Organization :

Other organizations : University of Minnesota

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

None explicitly mentioned

control variables

Lung tissue samples from control patients obtained by VATS biopsy or lobectomy

controls

Positive control: Fresh IPF lungs obtained at the time of lung transplantation
Negative control: Control lung tissue obtained by VATS biopsy or lobectomy

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